Abstract: AIM: To evaluate the therapeutic effect of artificial liver support system(ALSS)in the treatment of severe hepatitis.METHODS: Seventy patients with severe hepatitis were enrolled in two groups:treatment group(n=32)given ALSS combined with a routine treatment,and control group(n=38)only given the routine treatment.RESULTS: The liver functions of patients in treatment groupwere significantly improved after ALSS therapy.The total clinical efficacy rates in treatment groupand control groupwere 46.9% and 23.2%,respectively(p<0.05).The efficacy rates of patients receiving ALSS therapy in early,middle and late stage were 80.0%,50.0% and 10.0% respectively.CONCLUSION: ALSS is effective in treatment of severe hepatitis,especially in early and middle stage.

Key words: artificial liver support system, severe hepatitis, evaluation study