Abstract: AIM: To study the effects of bifendate on the blood concentration and hepatic toxicity of cyclosporine A in renal transplanted recipients. METHODS: 28 cases with renal transplantation in coadministration group were treated with CsA and BFD, and 30 cases with renal transplantation in control group received only CsA.Blood levels of CsA, biochemistry indexes for liver and renal function were determined. RESULTS: Blood concentrations of CsA in patients combined with BFD went down by 17.7 % compared with those before taking BFD and had a significant decrease compared with control group.Blood concentrations of CsA were significantly increased after stopping BFD administration.Mean blood concentrations were increased by 36.3 %.BFD could effectively reduce higher ALT and AST. CONCLUSION: BFD can markedly decrease the blood concentration of CsA in renal transplanted recipients.

Key words: bifendate, renal transplanted recipients, cyclosporin A, hepatic toxicity, drug concentration in blood