Effects of tetramethylpyazine injection on isolated tracheal smooth muscles of guinea pigs

Abstract

Abstract: AIM: To investigate the effects of tetramethylpyazine (TMP) on isolated trachea of guinea pigs. METHODS: The contraction effects were observed from the isolated tracheal smooth muscles. RESULTS: TMP had a significant relaxing effect of concentration-dependent on isolated tracheal smooth muscles and the effect was antagonized by propranolol.It had also obvious synergism to nifedipine in the direct relaxation to the isolated tracheal smooth muscles.Atropine had no effect on the relaxation of the TMP. CONCLUSION: TMP has a significant relaxing effect on isolated tracheal smooth muscles of guinea pigs.The effect is related with β2 receptors and inhibiting calcium inflow.

Key words: tetramethypyazine, isolated tracheal smooth muscles, guinea pig, pharmacology, β₂ receptor, calcium channel

CLC Number:

R285.5

YANG Yan-Qiu, LI Riu-Fa, XU Ji-De, FANG Mao, WU Jie, Huang Wen-Xian. Effects of tetramethylpyazine injection on isolated tracheal smooth muscles of guinea pigs[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(5): 558-560.

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Effects of tetramethylpyazine injection on isolated tracheal smooth muscles of guinea pigs

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