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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2005, Vol. 10 ›› Issue (9): 1001-1004.

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Ultrasonic study on effects of simvastatin on left ventricular mass in patients with essential hypertension

ZHANG Ping-yang, DENG You-bin1, YANG Hao-yi1, PAN Min1, BI Xiao-jun1   

  1. Department of Cardialvascular Ultrasonography, First Hospital of Nanjing Affiliated to Nanjing Medical University, Nanjing 210001, Jiangsu, China;
    1Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China
  • Received:2005-06-09 Revised:2005-08-31 Published:2020-11-22
  • Contact: ZHANG Ping-yang, male, professor, PHD/MD ( medicine doctorate), tutor of graduate student, president of department of cardialvascular ultrasonography, engaged in ultrasonography and ultrasonic study of medi cine. Tel:025-85223915 86624213-8698 E-mail:Zhpy28 @hotmail.com

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Abstract: AIM: To evaluate the effect of simvastatin on the left ventricular mass in patients with essential hypertension (EH).METHODS: 50 patients with hypertension without severe complication were randomly divided into two treatment groups:combination treatment group and hydragogue group, and 25 normal subjects without any treatment were taken as the control.The 25 patients in combination treatment group were given simvastatin and hydragogue for 12 weeks while the other patients in hydragogue group were given hydragogue during the same time.The left ventricular mass was examined from ultrasonography in all patients before and after treatment.RESULTS: The left ventricular mass index (LVMI) was higher in the two treatment groups of patients (133.61±31.02, 118.04±39.62 g。m-2) than that in the control group (88.79±22.73 g。m-2) before treatment (P <0.01, 0.0001, respectively) while the blood pressure was higher.There was no significantly difference in age, serum concentrations of total cholesterol or triglyceride, sugar and blood pressure between the two treatment groups and the control group (P >0.05).There was no significant difference in all variables between the two treatment groups before treatment.After treatment, the LVMI was decreased (133.61±31.02 vs 91.07±16.01 g。m-2, P <0.01) in the combination treatment group while there was no significant change in LVMI in the hydragogue group compared with the control group.The blood pressure in the two treatment groups was decreased to the normal.Compared with hydragogue group, the change of LVMI was higher in the combination group though the serum concentrations of total cholesterol, triglyceride or sugar were not significantly different.No significant change in serum concentrations of total cholesterol, triglyceride or sugar was found during treatment in the two groups.The change of LVMI did not correlate with the change of blood pressure, serum concentrations of total cholesterol, triglyceride or sugar in the combination treatment group(P >0.05).CONCLUSION: Being independent of the changes of serum concentrations of total cholesterol, triglyceride or sugar and blood pressure, simvastatin can inhibit the increase of left ventricularmass in patients with essential hypertension.

Key words: simvastatin, essential hypertension, left ventricular mass, ultrasonography

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