Welcome to Chinese Journal of Clinical Pharmacology and Therapeutics,Today is Chinese

Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2004, Vol. 9 ›› Issue (9): 978-982.

Previous Articles     Next Articles

Changes of caveolin-1 in development of atherosclerosis in apo E-deficient mice

QIN Li, QIN Xu-Ping, ZHU Bing-Yang, LIAO Duan-Fang   

  1. Institute of Pharmacy and Pharmacology, Nanhua University, Hengyang 421001, Hunan, China
  • Received:2004-07-22 Revised:2004-08-23 Online:2004-09-26 Published:2020-11-23

Abstract: AIM: To observe the changes of caveolin-1 in the development of atherosclerosis (AS) in apo E-deficient mice.METHODS: 40 male C57BL/6J mice and apo E-deficient mice were divided into two groups: control group and apo E-deficient mice group. The latterwere further divided into 3 subgroups depend on the survival weeks (10, 20, and 30 weeks). The serum total cholesterol, triglyceride, high and low density cholesterol were determined.The areas of aortic wall and plaque lesion were calculated. Immunohistology and western blotting were used for analyzed caveolin-1.RESULTS: The serum levels of total cholesterol, triglyceride and low density cholesterol in the apo E-deficient mice group were more significantly increased than those in the control group, the plaque areas and the ratio of plaque areas and aortic areas also increased. But the expression of caveolin-1 in aortic wall of the apo E-deficient mice group was more significantly decreased than those in the control group.CONCLUSION: The expression of caveolin-1 in aortic wall of the apo E-deficient mice decreased, which may be related to the formation of atherosclerosis.

Key words: caveolae, caveolin-1, apo E, atherosclerosis, gene-deficient

CLC Number: