Abstract: AIM: To investigate the value of color Doppler flow imaging (CDFI) and pulsed Doppler (PD) examination in evaluating chemotherapeutic effects of gestational trophoblastic disease (GTD). METHODS: Before and after chemotherapy, CDFI and PD were performed in 78 cases of GTD, and detected serum β-human chorionic gonadotropin (β-HCG) at the same time. RESULTS: For the blood flow of uterine muscular layer, the RI of uterine muscular layer, uterine and ovary artery in GTD, there were significant differences between before and after chemotherapy.A negative correlation was found between the increase of RI and the decrease of β-HCG (r =-0.54, P <0.001). CONCLUSION: The changes to the blood flow are the markers to evaluate chemotherapeutic effects in uterine muscular layer and the RI of uterine muscular layer, uterine artery, and ovary artery.CDFI and PD show a significant valuable for diagnosis, evaluating chemotherapeutic effects, and prognostic prediction of GTD.

Key words: obstetrics and gynecology, ultrasonography, Doppler, color, trophoblastic neoplasm, chemotherapy