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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2023, Vol. 28 ›› Issue (5): 583-593.doi: 10.12092/j.issn.1009-2501.2023.05.014

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Progress in the prevention and treatment of traditional Chinese medicine based on the mechanism of intestinal injury of various chemotherapy

LI Shuang 1,2, HAN Shuzhen3,4, DAI Yuting 5, XIU Minghui 1,3,5, DU Xianqin 1,2, HE Jianzheng1,3,4, LIN Xingyao 1,2   

  1. 1Provincial-level Key Laboratory for Molecular Medicine of Major Diseases and the Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and Universities, Lanzhou 730000, Gansu, China; 2Gansu Research Center of Traditional Chinese Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu, China; 3Key Laboratory of Molecular Medicine and Traditional Chinese Medicine Prevention and Treatment of Major Diseases in Gansu Universities, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu, China; 4School of Basic Medicine, Gansu Zhongshan University of Medicine, Lanzhou 730000, Gansu, China; 5School of Public Health, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu, China
  • Received:2022-11-21 Revised:2023-04-18 Online:2023-05-26 Published:2023-06-08

Abstract:

Intestinal injury is a common adverse reaction of clinical chemotherapy drugs, which limits the further application of chemotherapy drugs and causes serious physical and mental burden to patients. At present, the mechanism of chemotherapy-induced intestinal injury is complex, and traditional Chinese medicine has an excellent preventive effect. This article reviews the related mechanisms of intestinal flora imbalance, oxidative stress, inflammatory response, cell apoptosis, and immune damage caused by chemotherapy, and summarizes the role of traditional Chinese medicine in prevention and treatment of oxidative stress, inflammatory response, cell apoptosis , and immune damage.

Key words: chemotherapy, intestinal injury, mechanism, traditional Chinese medicine, prevention and treatment

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