Abstract: AIM: To investigate the protection effect of the total flavone from abelmoschus maniho L medic (TFA) on acute incompletely cerebral ischemia in rats. METHODS: The percentage of cerebral tissue waterbearing, permeability of cerebral vessel (OD tite), and pathology changes of cerebrum tissue were detected before and after the treatment of TFA.Ginkgo biloba extract, NS and sham operation were set as controls. RESULTS: In the acute incomplete cerebral ischemia models, TFA (50、 100mg ·kg ^-1, ig) could obviously reduce the water in the cerebrum in rats, and improve the pathology changes of cerebrum tissue in comparison with NS group. CONCLUSION: TFA shows a protective role on incomplete cerebral ischemia injury in rats.

Key words: pharmacology, abelmoschus maniho L medic, total flavone, cerebral ischemia, animal models