Abstract: AIM: To compare the clinical efficacy and safety of weilikang and domperidone in treatment of reflux esophagitis. METHODS: 80 cases of patients with reflux esophagitis were divided into two groups:one group patients were treated with Weilikang 10 g, po, tid;the other group ones was given domperidone, 10 mg, po, tid.The period of treatment all was 6 weeks. RESULTS: After 6 weeks, the total efficacy rates of weilikang and domperidone were 85.0% and 60.0% (P < 0.05), respectively. CONCLUSION: Weilikang can obviously relieve the clinical symptoms of patients with reflux esophagitis, its efficacy is better than that of domperidone, and the adverse reaction is slight.

Key words: pharmacodynamics, weilikang, domperidone, reflux esophagitis