Abstract: AIM: To study the effects of salvia miltiorrhiza compound and astragali in the treatment of patients with exacerbating chronic cor pulmonale. METHODS: 115 cases were randomly divided into two groups, with 56 cases in routine treatment group and 59 cases in salvia miltiorrhiza and astragali group.Besides routine treatment, such as oxygen therapy, ventilation improvement, administration of antibiotics, expectorant, and antiasthma, the patients in salvia miltiorrhiza and astragali group were treated with salvia miltiorrhiza compound and astragali, while subjects in routine treatment group were treated with routine therapy only. RESULTS: After treatment, the highly effective rates of two groups were 57.6% and 33.9%, and total effective rates were 98.3% and 89.3%, respectively.The therapeutic effect was significantly different (P <0.05) between the two groups. CONCLUSION: Salvia miltiorrhiza compound and astragali can improve the microcirculation and lower the pulmonary artery pressure and improve heart and lung function.

Key words: pharmacodynamics, cor pulmonale, salvia miltiorrhiza compound, astragali