Abstract: AIM: To establish a calculation of dosage regimen design on multiple dosing intravenous bolus injection administration of two-compartment model. METHODS: Microsoft EXCEL was used to write a program by the pharmacokinetic parameters to show the dosage regimen. RESULTS: The e-table displayed maximum dose (D_max) and minimum dose (D_min) of the administration after inputting parameters (α, β, K₂₁ and V₁ ), dosing interval (T_s), maximum toxic concentration(MTX) and minimum effective concentration(MEC).After inputting maintenance dose and cycle number (n), the e-table displayed plasma concentration at any time after the administration, including C_{(n, s) max} and C_{(n, s) min}, fractional number of reaching plateau, loading dose and accumulating time when the plasma concentration was above MEC in Ts or a cycle interval. CONCLUSION: This design method can provide safe and effective dosage regimen for clinical administration.

Key words: pharmacology, pharmacokinetics, dosage regimen, two-compartment model, EXCEL