Abstract: Aim The interaction of ampicillin(AMP) and chiorogenic acid (CHA), a primary component of Shuang huanglianpulv(SHLP)on urine pharmacokinetics in children was observed.Methods After a single ivdrip dose of 60 mg · kg^-1 SHLP or/and 150 mg ·kg^-1 AMP was given to the children infected in respiratory system, the concentrations of CHA and AMP in the urine collected a t varying time point s w ere determined by a high performance liquid chromatography (HPLC).Results Compared with CHA and AMP used alone, there was a decrease (P<0.05)in the discharge rate drugs within 24 h of the two the drugs used in combination from (51.7±15.6) % and (76.3±20.5)% to (42.1±12.2)%and (62.3±19.3)%for CHA and AMP respectively.The values of t_1/2 of CHA and AMP were increased from (3.44±1.14)h and (1.98±0.51)h to (4.33±1.38)h and (2.67±0.75)h(P<0.05).The results led to a decrease in ClR.Conclusion The discharge of CHA and AMP is decreased when SHLP and AMP are used in combination.

Key words: Shung huanglian pulv, chiorogenic acid, ampicillin, drug interactions