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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2002, Vol. 7 ›› Issue (2): 115-118.

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Expressions of nitric oxide synthase in neonatal rat after hypoxia-ischemia and their changes while ganglioside GM1 administrated1

HU Zhi-Bing, LU Xue-Fen2, ZHENG De-Shu2, DENG Ping, LI Wan-Mei   

  1. Department of Neurology, The 12th Hospital of Guangzhou, Guangzhou 510620;
    2Neuroscience Institute of Guangzhou Medical College, Guangzhou 510180
  • Received:2001-11-29 Revised:2001-12-25 Online:2002-04-26 Published:2020-11-27

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Abstract: AIM: To study the neuroprotective effect and possible mechanism of ganglioside GM1 on neonatal hypoxic-ischemic-encephalopathy( HIE).METHODS: A rat model of neonatal HIE was established, then the pathological changes and expressions of nitric oxide syn-thase (NOS) in the brain tissueswere investigated in dif-ferent periods after hypoxia-ischemia (HI) and the subse-qent changes of the above results after GM1 administrated. RESULTS: The damage of the brain exposed to HI were alleviated significantly after GM1 administrated.The lev-els of NOS expressions in the brain tissue increased after HI. GM1 could inhibit NOS expressions induced by HI.CONCLUSION: GM1 may have some protective effects on neonatal HIE, and the possible mechanism is related to the partial inhibition of NOS expression .

Key words: ganglioside GM1, hypoxic-ischemic-en-cephalopathy, neonatal rat, nitric oxide synthase

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