Abstract: AIM: To evaluate the therapeutic effect and safety of irbesartan in treatment of chronic congestive heart failure.METHODS: 80 patients with chronic congestive heart failure were randomizedly divided into the irbesartan group and the routine group, 40 cases in every group.The routine group was treated with nomal treatment digtoxin ethacrynicum and dilation vasocular, and the irbesartan group was treated with irbesartan 75-300 mg one time daily based on the nomal treatment.The course of treatment was 12 weeks.RESULTS: Irbesartan could improve symptom and heart function clearly (P< 0.01), and inccrease left ventricular ejection faction (LVEF).The reverse left ventricular mass weigh decreased more significantly than routine group (P< 0.05).Little side effect was found.CONCLUSION: Irbesartan has better curative effect and safety in patients with chronic congestive heart failure.

Key words: irbesartan, heart failure, left ventricular ejection faction, left ventricular mass weigh