Abstract: Aim The side and toxic effects on reproductive system of female rat caused by compositus GTW were observed. Methods In three dosages (11.27 g·kg^-1, 5.64.g·kg^-1and2.82g·kg^-1of each ary herbs), the 13 specified traditional Chinese medical herbs, including Trichosanthes Kirilowii, dendronium clavatum, Paeonia lactiflora,et al. were detected and concentrated to 10 ml·kg^-1 decoctums. The decoctums were each mixed with 30 g·kg^-1 GTW to compose the GTW compounds. GTW and GTW compounds, in the same dose, were given separetely to the rats in different groups for 80 days. Cytological examination was performed 10 days before finishing the experiment and changes of uterus and ovary were observed after the experiment.Results In the GTW group the ovulatory period was irregular, the weight of uterus was lost and its muscle became thinner, as compared with those in the control group, while in the GTW compound groups the toxic effects found in the GTW group were apparently redressed.Conclusion The side and toxic effects of GTW compound on reproductive system of female rats are apparently lower than those of GTW.

Key words: multiglycoside of tripyergium wilfordii, compound reproductive system