Abstract: Aim To compare the effectsof food on the bioavailability of two kinds of cinnarizine capsules (A and B). Methods HPLC method with UV detection was used to measure the serum cinnarizine concentration in 12 healthy human volunteers after a single 50mg oral dose both in fasting condition and with a meal. Results The peak plasma concentration (C_max)and the area under the plasma concentration time curve (AUC)of capsule A appeared to be unchanged in the presence of food, but food significantly affected the extent of absorption of capsule B. The C_max and AUC of capsule B in fasting condition were significantly less than those with a meal. Conclusion The formulation of capsule A had advantage over capsule B. Its bioavailability was not affected by food.

Key words: cinnarizine ;food ;bioavailability