Abstract: Aim To study the biological effect of extracts of solanum lyratumthumbon inducing apoptosis of BEL-7404 cell line.Methods The BEL-7404 cells were cultured in DMED medium and treated with extract of solanum lyratum thumb and then were observed with microscope and their DNA was assayed by the method of gel.Results Treatment by ex tract of solanum lyratum thumb could induce the cells to reveal atypical apoptotic appearance.Their DNA was fracted and a ladder pattern characteristic could be found by the elect ropho resis.The extract of solanum lyratum thumb show the same effects as paclitaxol. Conclusion solanum lyratum thumb can induce apoptosis in BEL-7404 cells.

Key words: solanum lyratum thumb, human hepotoma cell line BEL-7404, apoptosis