Abstract: Aim To study the effect of leuprorelin acetate microspheres (LE-ms)on endometriosis in rats, and compare the efficacy of material drug (LE), domestic and imported LE-ms (enanton).Methods Endomet riosis was induced by endomet rial implant in rats.Then the animals were treated with LE (20 μg· kg^-1·d^-1×28 d, sc), enanton(20 μg·kg^-1·d^-1, sc) and domestic LE-ms (2, 20, 200 μg·kg^-1·d^-1, sc). Results Implants in control group continued to grow, while those in groups treated with drugs shrinked signif icantly, and domestic LE-ms could produce dose-dependent inhibitory effect on the growth of endometrial implant in rats.Conclusion The domestic LE-ms at the single dose of 20 μg·kg^-1·d^-1 has the same effectiveness as enanton and routine injection with the same does of LE for 28 days.

Key words: leuprorelin, microspheres, endometriosis