Abstract: Aim To compare the relative bioavailabilities of domestic acyclovir chewable tablets and normal tablets. Methods A single oral dose of 800 mg acyclovir chew able tablets or normal tablets was given to 8 volunteers respectively in a randomized, cross-over study, acyclovir serum concentration was determined by high performance liquid chromatography. Results The AUC of chewable nd normal tablets was respectively 0.42 and 0.40μg·ml·h^-1, and the relative bioavailability of acyclovir chewable tablets was (105.8±13.1) %. Conclusion The chewable tablets and reference tablets is bioequivalent in AUC.

Key words: acyclovir, bioavailability, HPLC, bioequivalence