Abstract: Aim To study relative bioavailablity of cefacloreffervescent tablets in healthy volunteers.Methods According to the crossover design, Avolunteers wereeach orally g iven a sing le does of the 0.75 g cefacloreffervescent tablets and cefaclor capsules with an interval of 5 days between the twoformulations.The plasma concentrations of the drug weredetermined by RP-HPLC.Pharmacokinetic parameters wereobtained by A TPK programe, and calculated on the basis of open sing le compartment model.Results After a single oral dose, the peak levels in plasma averaged C_max(31.27±5.81) μg·ml^-1 and(30.56±5.25) μg·ml^-1 at (0.58±0.12) h and(0.73±0.17) h and AUC_0~4(35.48±4.65) μg·h·ml^-1 and (35.89±2.90) μg·h·ml^-1 for tablet and capsule, respectively.Conclusion Theresult show s that twoformulations arebioequivalence.

Key words: cefaclor, effervescent tablets, relative bioavailability, reversed phase-high performance liquid chromatographay