Abstract: Aim To study the Effect of Baoxinbaofilm on endothelin(ET)and nitricoxide(NO)secretion in patients with stable angina pectoris(SAP).Methods 76 patients with SAP wererandomly dividedinto two groups, with 40 cases in the baoxinbao group plastered with baoxinbaofilm and 36 cases in the isosorbide dinitrate groupreceiving isosorbide dinitrate. The levels of plasma E T and NO beforeand after treatment wereobserved.Results The concentrations of plasma E T wereincreased and plasma NO reduced significant ly in the SAP patients respectively, as compared with those in the control group(all P<0.01).After treatment the metabolic imbalance of ET and NO was improved markedly in both Baoxinbao andisosorbide groups(P<0.05, P<0.01), but the imbalance of ET and NO in the Baoxinbao group was improved moreobviously than thatin the isosorbide group(P<0.05).Conclusion Baoxinbaofilm can obviously improve the metabolic imbalance of ET and NO secretion,which results in the effective alleviation of angina pectoris in patients with SAP.

Key words: baoxinbaofilm, endothelin, nitricoxide, angina pectoris