Abstract: Hepatitis B recurrence is an important factor to show whether liver transplantation is successful or not.Recrrrence rate is nearly 80 % in the patients liver transplantation, and HBV reinfection is the main cause of death.After the operation, HBV may copy very quickly, because of taking in immunosuppressant therapy and graft diseases develop rapidly.Recently, the exploitation and application of therapy has becomea focus.Now the drugs of preventing and treating HBV reinfection are mainly sortedinto passive immunity agents (Hepatitis B im-munoglobulin) andantivirus therapeutic agents(interferon and nucleotide analog antivirus drugs, etc)..Lamivudine is considered the most promising new drug of treating HBV infection.This article introduced the therapeutic characteristic of these drugs.

Key words: liver transplantation, hepatitis B recur-rence, antivirus therapy