Abstract: Aim To observe the relation between cardiac diastolic function and the clinical efficacy of Venous thrombolytic therapy on acute myocardial infarction (AMI).Methods In 50 patients.with AMI receiving venous thrombolytic therapy the ratio of velocity area of peak A/ peak E (VA/VE)from mitral flow , left ventricular ejection fraction (LVEF), fractional shortening at minor axis (FS)were measured by Color Dopplet Flow Imeging, HP2500 and clinical cardiac functions were judged by killip grades.Results (1)There were no differencies in age, sex, AMI locations, clinical cardiac function， LVEF, FS and histories of hypertension, diabetes and old myocardial infarction both among 36 cases of reperfusion and 14 cases of nonreperfusion (all P>0.05).(2)The ratio of VA/VE was lowwer in the reperfusive group than that in non-reperfusive group (1.0129±0.3427 us 1.3335±0.4077, P<0.01);patients with VA/VE> 1 less in reperfusive group (47.2% us 85.77%，P< 0.05).Conclusion There might be more protective efficacy on left ventricular diastolic function after IRA reperfusion in AMI cases treated by venous thrombolytic therapy.

Key words: acute myocardial infarction, thrombolytic therapy, cardiac function