Abstract: Aim To study the pharmacokingtics character of ondansetron in patients with primary carcinoma of liver.Methods Ondansetron was given po both in a single dose of 16 mg and in multiple doses of 16mg each and its concent ration in plasma was determined by reve rsed-phase high performance liquid chromatography.The concent ration data were fitted with a PKBP-N₁ program on computer.Results The concent ration-time curve was described by a two-compartment open model with T_1/2ka=0.8±0.1h and 0.7±0.1h, T_1/2α=1.9±0.4h and 1.8±0.3h, T_1/2β=4.3±0.5h and 5.7±0.7h, C_max=42.6±3.8μg/L and 49.2±2.3 μg/L, T_max = 1.8±0.2h and 1.8±0.1h, AUC_0~∞=643±85 μg/h·L and 833±97 μg/h·L, respectively.Conclusion Ondansetron was absorbed repidly, and also eliminated at a fairly rapid rate.It could be stored up in the patients contrating primary carcinoma of liver when ondansetron is admani steaed in multiple doses.

Key words: Ondansetron, primary carcinoma of liver, pharmacokinetics