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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2023, Vol. 28 ›› Issue (9): 1073-1080.doi: 10.12092/j.issn.1009-2501.2023.09.015

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Recent progress in understanding the neuroprotective mechanism of carnosic acid in Parkinson's disease

WANG Jingang1, LI Qiang1, SUN Huiyan2,WANG Hongquan3   

  1. 1The Affiliated Hospital of Chifeng University, Chifeng 024000, Inner Mongolia, China; 2Chifeng University Health Science Center, Chifeng 024000, Inner Mongolia, China; 3Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
  • Received:2023-05-15 Revised:2023-07-10 Online:2023-09-26 Published:2023-09-25

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Abstract: Carnosic acid (CA) is a natural phenolic diterpene compound found in rosemary (Rosmarinus officinalis) characterized as an ortho-dihydroquinone-type molecule.Multiple lines of studies have shown that CA has potent neuroprotective effects in vitro and in vivo in Parkinson's disease (PD). The aim of the present review is to summarize the pharmacological neuroprotective actions of CA, and provide a comprehensive review of the molecular mechanism by which CA exert neuroprotective effect in PD. The current review highlights CA is a therapeutic potential for PD.

Key words: carnosic acid, rosemary, Parkinson's disease, neuroprotection

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