Research progress on the protective mechanisms of curcumin on cerebral ischemia-reperfusion injury

doi:10.12092/j.issn.1009-2501.2019.11.015

Abstract

Abstract:

Ischemic stroke is a major cause of death and disability in the world. Currently, the most effective treatment for ischemic stroke is to prevent ischemia and hypoxia injury and repair damaged tissues by restoring blood flow (reperfusion). Although reperfusion is a signal for the termination of ischemia and hypoxia, it may subsequently increase cell damage and death through excessive production of reactive oxygen species, abnormal recruitment of inflammatory cells, and excessive release of inflammatory factors, autophagy, mitochondrial dysfunction, calcium homeostasis disorder, endoplasmic reticulum stress, glutamate excitotoxicity, apoptosis, destruction of blood-brain barrier and other mechanisms. A large number of studies have shown that curcumin can play a significant neuroprotective effect by slowing down various pathological mechanisms of ischemia-reperfusion injury, and ultimately improving cerebral circulation, reducing infarct volume, reducing cerebral edema, promoting blood-brain barrier repair, and improving neurological function. Therefore, curcumin can improve neurological function by alleviating ischemia-reperfusion injury, and has the potential to supplement the existing treatment methods for ischemic stroke.

Key words: curcumin, cerebral ischemia-reperfusion injury, neuroprotection

CLC Number:

R741

LIU Xiaoyan, TIAN Ye, LIU Jifei, SU Gang, ZHANG Zhenchang. Research progress on the protective mechanisms of curcumin on cerebral ischemia-reperfusion injury[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(11): 1305-1309.

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