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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2023, Vol. 28 ›› Issue (11): 1283-1291.doi: 10.12092/j.issn.1009-2501.2023.11.011

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Research progress on the role of the Nrf2 signaling pathway in the complications associated with obstructive sleep apnea

ZHU Haobin1, YUE Hongmei1,2, WU Xingdong1, LIU Miaomiao1, LI Yating 1, XU Jinhui1   

  1. 1The First Clinical Medical College of Lanzhou University, 2Department of Respiratory and Critical Care Medicine, Lanzhou University First Hospital, Lanzhou 730000, Gansu, China 
  • Received:2023-04-26 Revised:2023-07-03 Online:2023-11-26 Published:2023-11-10

Abstract:

Mammalian cell defense mechanisms are constantly evolving in response to increasing endogenous and exogenous oxidative stress factors. In recent years, as research has deepened, nuclear factor E2-related factor 2 (Nrf2) has been hailed as a "star" molecule in antioxidant damage defense. Billions of dollars have been spent internationally on developing targeted activators or inhibitors. Obstructive sleep apnea (OSA) is the most common form of sleep breathing disorder in clinical practice. Oxidative stress is one of its main pathological mechanisms and is closely related to target organ damage in the heart, brain, lungs, kidneys, and other systems. Recent research has revealed the mechanistic relationship of the Nrf2 pathway in OSA complications, and some natural Nrf2 activators have demonstrated emerging therapeutic effects in animal experiments. However, the activation mode and effect pathway of Nrf2 in different target organs of OSA have not been clarified. Therefore, this article reviews the research progress of the Nrf2 pathway in OSA and its complications, to deepen understanding of the mechanism of OSA complications and provide a potential treatment strategy.

Key words: obstructive sleep apnea, nuclear factor e2 correlated factor 2, oxidative stress

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