Abstract: AIM: To evaluate the effects of induction with midazolam on postoperative anesthesia recovery quality in aged patients received laparoscopic cholecystectomy.METHODS: 54 ASAⅠ-Ⅱelderly patients aged 65-75 years undergoing elective laparoscopic cholecystectomy were randomly divided into 2 groups(n=27); experimental group(Group M) and control group(Group P).Midazolam 0.05 mg/kg, propofol 0.6-0.8 mg/kg, fentanyl 4 μg/kg and atracurium 0.7 mg/kg were intravenously administered during induction in Group M,wheareas in Group P ,anesthesia was induced with propofol 1-1.5 mg/kg, fentanyl 4 μg/kg and atracurium 0.7 mg/kg. The patients were mechanically ventilated.Anesthesia was maintainded with propofol and sevoflurane. The SBP,DBP and HR were recorded immediately before anesthesia induction (T₀),1 min after intubaion (T₁), pneumopetitonium (T₂),at the end of surgery(T₃),immediately and 1 min,5 min,10 min after extubation (T_4,5,6,7). Times of open eyes,extubation,staying at PACU and being wide awake were recorded. Adverse events after extubation and Ramsay score 10 minutes after extubation were observed.RESULTS:Compared with Group P, the time of open eyes and extubation were significantly prolonged(P＜0.05) and the rates of post-extubation respiratory depression, glossoptosis and drowsiness were significantly increased in Group M(P＜0.05).The number of samples of Ramsay score grade 3 or 4 at 10 min after extubation in Group M was increased(P＜0.05).The SBP,DBP and HR at T₄ ,T₅ were obviously increased than those at T₀ in the two groups.There was statistically difference between the two groups (P＜0.05).CONCLUSION: Midazolam might result in postoperative recovery delay in elderly patients, and it could increase the rate of post-extubation respiratory depression,glossoptosis and drowsiness.

Key words: Midazolam, Aged, Anesthesia, General, Recovery quality