Abstract: AIM: To compare the difference of effect and side effects of Sulpiride with Paroxetine and Olanzapine with Paroxetine in the treatment of anorexia nervosa. METHODS: 57 anorexia vervosa patients were involved in the research, including 25 cases of Sulpiride group,32 cases of Olanzapine group, before and after the treatment, body weight, body mass index (BMI), Hamilton anxiety scale (HAMA), Hamilton depression rating scale (HAMD) and Treatment emergent side-effect scale (TESS) were used to evaluate the curative effect and the adverse drug reactions. RESULTS: After 8 weeks treatment ,the indexes of body weight, BMI, HAMA,HAMD were obviously better than those of before treatment (P<0.05). The indexes of body weight and BMI of Olanzapine group were better than those in Sulpiride group after 8 weeks treatment (P<0.05), but there were no difference of HAMA,HAMD and TESS between two groups(P>0.05) . CONCLUSION: After analysis of the indexes as body weight, BMI, HAMA, HAMD and TESS, the following conclusions are made: the two methods are both effective to the treatment of anorexia noversa, but the Olanzapine with Paroxetine is better than Sulpiride with Paroxetine in improving the body weight and the BMI. The difference of the adverse drug reactions is not found in the two groups.

Key words: Anorexia nervosa, Sulpiride, Olanzapine, Body mass index(BMI)