Association study of ERCC1 and ERCC4 genetic polymorphism with response and survival in non-small cell lung cancer patients treated with cisplatin-based chemotherapy

Abstract

Abstract: AIM: To evaluate the effect of the polymorphisms of excision repair cross-complementation group 1(ERCC1) and excision repair cross-complementation group 4 (ERCC4) on response and progress free survival in non-small cell lung cancer patients treated with cisplatin-based chemotherapy.METHODS: ERCC1 and ERCC4 were genetyped by polymerase chain reaction restriction fragment length polymorphism. The relationship between response, progress free survival and genetype was analyzed.RESULTS: Compared with patients carrying C/T and T/T in ERCC1 C118T, carrying genotype C/C were more likely respond to chemotherapy(20.6% vs 29.6%; 77.8% vs 73.5%) , but there is no significant difference in response and progress free survival in patients at ERCC1 C118T genotype. Compared with patients carrying C/T and T/T in ERCC4 -673C>T, carrying genotype C/C tended to get less clinical benefit from chemotherapy(72.5% vs 81.0%), any associativity between ERCC4 -673C>T genotype and response, progress free survival in patients receiving cisplatin based chemotherapy was unfounded.CONCLUSION: Genetic polymorphism of ERCC1 and ERCC4 were not associated with response and progress free survival in non-small cell lung cancer patients treated with cisplatin-based chemotherapy.

Key words: Non-small cell lung cancer, Cisplatin, Genetic polymorphism, ERCC1, ERCC4

CLC Number:

R969

HUA Zhi-hui, FANG Wen-zheng, ZHAO Zhong-quan, XIE Fang-wei, OU YANG Xue-nong, SONG Hong-tao. Association study of ERCC1 and ERCC4 genetic polymorphism with response and survival in non-small cell lung cancer patients treated with cisplatin-based chemotherapy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(7): 772-778.

References

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