Abstract: AIM: To explore the effect of hemodynamics and emergence time when dezocine is used in the periextubation period of endoscopic sinus surgery.METHODS: 60 patients treated with endoscopic sinussurgery were divided into three groups randomly, the group Ⅰ,including 11 men and 9 women, were injected with dezocine 0.1 mg/kg,and the group Ⅱ(12 men and 8 women) was injected with Fentanyl 0.002 mg/kg,and the group Ⅲ,including 9 men and 11 women, was injected with normal saline 1 mL when the surgery is over. The index of bloodstream dynamics stable and limitation to wake among the three groups was observed. The patients were induced tracheal intubation by intravenous injected midazolam,propofol,and cisatracurium. Sevoflurane was inhaled and the propofol was intravenous injected during operation.RESULTS: The emergence time among the three groups had no statistics difference(P＞0.05). Compared with the group Ⅰ and group Ⅱ,the hemodynamics in the periextubation period of endoscopic sinus surgery was stable in the group Ⅲ,there was significant difference(P＜0.05).CONCLUSION: The circulatory dynamics is stable during extubation in the group Ⅰ,and there is no effect on emergence time.The dezocine is effective and safe when using at the the periextubation period of endoscopic sinus surgery.

Key words: Dezocine, Fentanyl, Endoscopic sinus surgery, Emergence time, Hemodynamics