Abstract: AIM: To observe the changes of the serum high sensitive C-reactive protein (hs-CRP) levelsand the insulin sensitivity index before and after using Metformin or intensive lifestyle intervention treatment.METHODS: 176 prediabetes patients were randomly divided into Metformin treatment group, intensive lifestyle intervention group and Control Group. Metformin treatment group 52 cases, in general,was given on the basis of lifestyle intervention of Metformin tablets; The intensive lifestyle intervention group 60 cases, based on individual eating habit, and was developed energy,given low-fat diet, control diet, with a reasonable, balanced diet, coupled with adequate physical exercise.64 patients in the Control Group, only to give general lifestyle intervention.The fasting blood glucose,2-hour postprandial blood glucose, glycated hemoglobin, body mass index, blood lipids, hs-CRP, insulin sensitivity index changes were determined before and after intervention.RESULTS: After intervention for 2 years, 21 impaired glucose tolerance patients(32.81%)became normal glucose tolerance,and 12 patients (18.75%) were converted to diabetes patients in the Control Group.41 impaired glucose tolerance patients(78.85%)became normal glucose tolerance,and 3 patients (5.77%) were converted to diabetes patients in the metformin treatment group. 32 impaired glucose tolerance patients(53.33%)became normal glucose tolerance,and 4 patients (6.67%) were converted to diabetes patients in intensive lifestyle intervention group.Compared with the Control Group, the incidence of diabetes was significant in the Metformin treatment group and intensive lifestyle intervention group (P<0.05).After intervention for 2 years,the changes of the indexes were significant in the Metformin treatment group and intensive lifestyle intervention group(P<0.01).The Metformin treatment group had better results than intensive lifestyle intervention group (P<0.01).CONCLUSION: Prediabetes, the serum hs-CRP levels have been increased, and the insulin sensitivity has been decreased, metformin or intensive lifestyle intervention therapy can significantly reduce the blood sugar and the serum hs-CRP levels and improve the insulin sensitivity, and the Metformin effects is obvious.

Key words: C-reactive protein, Insulin sensitivity, Prediabetes, Metformin, Intensive lifestyle