Advances in the influence of MDR1 gene polymorphisms on pharmacokinetics of related drugs

Abstract

Abstract: Transport proteins involve in drug disposition in vivo. P-glycoprotein, encoded by multidrug resistance1, accelerates the drug efflux from those tissues.MDR1 gene polymorphisms not only has an direct influence on the distribution and function of P-gp, but also has an impact on the disposition of its substrates.Further study of physiological and biochemical function on different genetype encoding P-gp could be very important in individual treatment.This article reviews recent studies of influence of single nucleotide polymorphisms of MDR1 gene on the pharmacokinetics of substrates and this can provide references for clinical individualized therapy.

Key words: MDR1, Gene polymorphisms, P-glycoprotein, Pharmacokinetics

CLC Number:

R968

DING Zheng, DENG Jie, SONG Hong-tao. Advances in the influence of MDR1 gene polymorphisms on pharmacokinetics of related drugs[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(10): 1191-1196.

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