Verapamil enhanced the analgesic effect of ketamine in mice

Abstract

Abstract: AIM: To observe the analgesic effects of ketamine combind with verapamil in mice.METHODS: 40 mice were randomly divided into 4 groups: normal saline group (NS), ketamine group (K), verapamil group (V) and verapamil combind with ketamine group (V+K). The method of stretching induced by acetic acid was adopted. In another experiment, 40 mice were randomly divided into 4 groups above. The pain thresholds of mice to hot and ice water were observed through tail-flick experiment.RESULTS: Ketamine prolonged stretching latent time and reduced the stretching times. In addition, ketamine increased tail-flick pain threshold to hot or ice water. These analgesic effects of ketamine were markedly enhanced by verapamil.CONCLUSION: Verapamil can significantly enhance the analgesic effect of ketamine in mouse.

Key words: Verapamil, Ketamine, Analgesic effect, Mouse

CLC Number:

R614

WU Yu-qing, ZHOU Cheng-hua, ZHANG Yong. Verapamil enhanced the analgesic effect of ketamine in mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(11): 1201-1204.

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