Abstract: AIM: To observe the prevention of montelukast sodium on wheezing infants of non-specific symptoms.METHODS: A total of 80 infants (Eosinophil＜0.04, the serum total IgE was normal) were randomly divided into two groups: the treatment group (40 patients) and control group (40 patients). The patients in montelukast sodium treated were taken 4 mg once daily by routine complex treatment for 4 months. The two groups were followed up for 1 year. The serum total IgE and eosinophil of all patients were determined, the recurrent wheezing was observed.RESULTS: The serum total IgE and eosinophil were same in both groups (P>0.05), there were significant decrements in wheezing infants in 1 year (P<0.05).CONCLUSION: Oral administration montelukast sodium is effective, and it can reduce course of the illness and prevent recurrent wheezing in infants.

Key words: Montelukast sodium, Wheezing infants of non-specific symptoms, Effective