Abstract: AIM: To study the clinical curative effect of keluoxin collocystis combined with enalapril in treatment of diabetic nephropathy.METHODS: Forty three patients with early diabetic nephropathy and 37 patients with clinical diabetic nephropathy were randomly divided into enalapril control group and keluoxin combined with enalapril treated group,the tota1 course of treatment was 2 months.RESULTS: After 2 months of treatment,the levels of TC,TG and LDL-C in treated group were decreased obviously (P<0.05,P<0.01),the level of HDL-C was elevated obviously (P<0.05)in treated group,while there were no significant difference of TG, TC, LDL-C and HDL-C in control group.The UAER, α₁-MG、β₂-MG were decreased significantly in both groups in early diabetic nephropathy(P<0.05,P<0.01),but more significant in treated group than that in control group (P<0.05).The urine protein quantitative, urinaryα₁-MG, urinaryβ₂-MG and blood albumin were improved significantly in both groups in clinical diabetic nephropathy(P<0.05,P<0.01),but more significant in treated group than that in control group (P<0.05);the serum creatinine (Scr) in the clinical DN patients of control group was no obvious improvement (P>0.05),but the Scr in treatment group was improved significantly (P<0.05).CONCLUSION: Keluoxin combined with enalapril in treatment of DN patients has better effectiveness in reducing albuminuria and in improving renal function than enalapril alone.The data indicates that the combination of the two drugs can help each other against DN development. Keluoxin combined with enalapril are effective in treatment of diabetic nephropathy.

Key words: Diabetic nephropathy, Keluoxin, Enalapril