Abstract: AIM: To investigate the clinical efficacy of carboprost tromethamine on the prevention and treatment for hemorrhage during cesarean section (CS) and postoperative hemorrhage. METHODS: From Feb. to Oct. 2011, 120 cases undergone CS with high risk of PPH were divided randomly into two groups. After delivery 250 μg carboprost tromethamine was injected on the uterine body in study group, while methyl-carboprost suppository 1.0 mg by sublingual was given immediately in control group,both on the basis of oxytocin intravenous drip. The intraoperative blood loss, postpartum bleeding in 2 h and 2-24 h and the rate of postpartum hemorrhage were compared between two groups. The changes of vital signs before and after the treatment in two groups were observed. RESULTS: There were statistically significant differences between two groups on intraoperative blood loss, postpartum hemorrhage in 2 h and 2-24 h (P<0.05); And the incidence rate of postpartum hemorrhage in study group was less than that in control group(P<0.05). There were no significant differences on the change of vital signs before and after treatment (P>0.05)CONCLUSION: It was effective, rapid and convenient to use carboprost tromethamine for the prevention and treatment in high hemorrhagic risk fators of PPH during CS with less adverse reaction.

Key words: Carboprost tromethamine, Cesarean section, Postpartum hemorrhage, High risk parturient