Abstract: AIM: To investigate the effect of intravenous infusion with hypertonic sodium chloride hydroxyethyl starch 40 injection(HSH40) on cytokines of patients with septic shock. METHODS: 60 operated patients with intestinal obstruction and septic shock were randomly divided into two groups (30 in each group). Therapy group (Group Ⅰ)was administrated with HSH40 at a dose of 10 mL/kg for 30 min after anesthesia induction. Control group (Group Ⅱ) was received the same amount of lactated Ringer's solution(LRS). Blood samples were taken at the following time point, immediately enter the operation room(T₀), at 30 min after infusion(T₁) and at the end of surgery(T₂), the levels of TNF-α, IL-1β, IL-6 and IL-10 in plasma were measured by ELISA. RESULTS: Compared with T₀, the levels of plasma TNF-α, IL-1β and IL-6 were decreased at T₁ and T₂ in groupⅠ (P＜0.05), while the level of plasma IL-10 was increased (P＜0.05). Compared with group Ⅱat T₁ and T₂, the levels of plasma TNF-α, IL-1β and IL-6 were decreased in groupⅠ (P＜0.05), while the level of plasma IL-10 was increased (P＜0.05). Compared with T₀, the levels of plasma TNF-α, IL-1β, IL-6 and IL-10 at each time point had no significant difference in GroupⅡ(P＞0.05). CONCLUSION: HSH40 may modulate the inflammation response during septic shock.

Key words: Hypertonic sodium chloride hydroxyethyl starch 40 injection , Shock, Septic, Cytokine