Abstract: AIM: To investigate PTEN and LIVIN expression in diffuse large B-cell lymphoma and evaluate their clinical significance. METHODS: From July 2008 to May 2011,41 cases of untreated diffuse large B-cell lymphoma (DLBCL) specimens and 21 cases of benign lymph nodes hyperplasia(BLH) were selected from Affiliated Hospital of Wannan Medical College.The expressions of PTEN and LIVIN in the 41 cases of DLBCL and 21 cases of BLH were measured by means of immunohistochemical S-P staining method and the relationships of PTEN and LIVIN expressions with diffuse large B-cell lymphoma stage and prognosis were evaluated. RESULTS: The positive rate of PTEN expression was 39.00% in the diffuse large B-cell lymphoma tissues,it was 80.95% in the benign lymph nodes hyperplasia tissues(P<0.05). The positive rate of LIVIN expression was 65.90% in the diffuse large B-cell lymphoma tissues,it was 23.81% in the benign lymph nodes hyperplasia tissues(P<0.05). PTEN were not positively related to the patient's gender,age, physical score, clinical stage,extranodular invasion,LDH, International Prognosis Index or the molecular type.LIVIN were not positively related to the patient's gender,age, clinical stage or extranodular invasion(P>0.05). LIVIN were positively related to the patient's physical score,LDH,group B, molecular type and International Prognosis Index(P<0.05). PTEN and LIVIN were inverse correlation in diffuse large B-cell lymphoma. CONCLUSION: There are overexpressions of LIVIN in the diffuse large B-cell lymphoma.PTEN expresses in contrast .The positivity rates of PTEN is related to the group A and molecular type,while LIVIN are related to the patient's physical score,LDH,group B,molecular type and International Prognosis Index. PTEN may not predict the outcome in DLCBL.LIVIN might serve as biomarkers to the diffuse large B-cell lymphoma prognose.

Key words: PTEN, LIVIN, Immunohistochemistry, Diffuse large B-cell lymphoma