Abstract: AIM: To observe the effectiveness of methotrexate combined with mifepristone for tubal pregnancy treatment. METHODS: A total of 98 cases of ectopic pregnancy were diagnosed as unrupture tubal pregnancy that be randomly divided into two groups from Jan. 2008 to Jun. 2010, each group 49 cases. Study group was treated with MTX single-dose (50 mg/m²) intramuscular injection combined with mifepristone. Control group was treated with MTX single-dose (50 mg/m²) intramuscular injection only .After treatment, the curative effect and adverse effect between the two groups were compared. RESULTS: The rate of tubal pregnancy package of block reduction and the serumβ-HCG descent exceeded 30% in study group. Less time of average hospitalization in study group significantly differed from the control group (P<0.05). And the lateral oviduct recanalization rate of the study group was 75.0%(24/32),which was higher than that of the control group 64.3%(18/28). CONCLUSION: The combination of single-dose MTX intramuscular injection with mifepristone in treating tubal pregnancy is effective and has minor side effect. The procreation function is reserved and it is acceptable for patients.

Key words: Methotrexate, Mifepristone, Tubal pregnancy