Pharmacokinetic interactions of HIV protease inhibitors

Abstract

Abstract: HIV protease inhibitors are the frontline drugs for the management of acquired immune deficiency syndrome during its long-term therapy. A combined medication of HIV protease inhibitors with other drugs is often used when the patients are accompanied with other diseases or complications. As is known, HIV protease inhibitors have extensive pharmacokinetic effects on cytochrome oxidase P450s and transporters so that drug interactions may take place, which are negative to clinic therapy. In this article, we review the relevant reports on drug interactions between HIV protease inhibitors and other drugs, and amongst themselves, putting more emphasis on mechanism-based pharmacokinetic interaction. Hopefully, this summary can be useful to evaluate clinic regiment designs and improve safety and efficacy of drugs in a combined medication.

Key words: HIV protease inhibitors, Interactions, CYP450, P-gp

CLC Number:

R969. 2

GU Rong-rong, SHI Jian, A Ji-ye, WANG Guang-ji. Pharmacokinetic interactions of HIV protease inhibitors[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(4): 472-480.

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