A Meta-analysis of histamine-receptor antagonists use and risk of pneumonia

Abstract

Abstract: AIM: To evaluate whether the use of histamine-receptor antagonists will increase the risk of pneumonia.METHODS: By searching EMBSE , CENTRAL(the Cochrane central register of controlledtrials), CBM, Medline, CNKI and WANFANG et al , we collected published randomized controled trials(RCTs) about histamine use and risk of pneumonia.The effect size was incidence of pneumonia measured relative risk (RR) and its 95% confidence interval (95%CI).The cochran's chi-square test (Q test) was used to test the statistical heterogeneity.The Egger test was used to test the publication bias.RESULTS:18 trials that included a total of 2974 subjects were included in the meta-analysi.1508 subjects were in the histamine-receptor antagonists group and 1466 were in the placebo of sucralfate group.The pooled relative risk of pneumonia was higher in histamine-receptor antagonists group compared with placebo/sucralfate group(RR=1.22,95%CI=1.05-1.41,Z=2.61,P=0.009). Sub-group analysis ,the pneumonia risk was increase 21% in histamine-receptor antagonists group compared with placebo group(RR=1.21, 95%CI=1.02-1.45,Z=2.17,P=0.03).But statistical difference was observed between histamine-receptor antagonists group and sucralfate group RR=1.22, 95%CI=0.93-1.60,Z=1.45, P=0.148).CONCLUSION: The use of histamine-receptor antagonists may increase the risk of pneumonia.

Key words: Pneumonia, Histamine-receptor antagonists, Meta-analyis

CLC Number:

R311

HU Ai-hong, LI Xiao-ming, MA Huan-jie. A Meta-analysis of histamine-receptor antagonists use and risk of pneumonia[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(5): 536-542.

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