Renal protective effect of sesamin in spontaneously hypertensive rats

Abstract

Abstract: AIM: To evaluate the protective effect of sesamin on kidney damage in spontaneously hypertensive rats (SHR).METHODS: Sesamin(160,80,40 mg/kg)was administrated to SHR intragastrically once a day for 16 weeks. The blood pressure (BP) before and after administration were measured. After the last BP measuring, rats were anesthetized. 5 mL of blood sample were collected from abdominal aorta for the detecting of blood urea nitrogen (BUN) and creatinine(Cr) concentration. The kidney was excised for HE and MASSON staining to observe the changes of pathology and collagen fibers. Glomerular ultrastructure was observed by transmission electron microscopy.RESULTS:After the administration of sesamin for 16 weeks, the BP,Cr and BUN were lowered significantly. Pathological changes such as glomerular distortion, atrophy, sclerosis and hyalinization were improved. There was no significant expansion in mesangial area, no thickening in basement membrane and no significant cell fusion of podocytes. Renal tubular cell injury and interstitial fibrosis was significantly reduced.CONCLUSION: Sesamin can improve the renal function of SHR kidneys and protect kidneys from damage.

Key words: Sesamin, SHR, Kidney, Pathological changes, Glomerular ultrastructure, Interstitial fibrosis

CLC Number:

R965.2

DU Shao-ling, YANG Jie-ren, ZHANG Jun-xiu, LI Wen-xing. Renal protective effect of sesamin in spontaneously hypertensive rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(5): 502-507.

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