Experimental study of Pearl Bright Eyedrop on rabbit eyes ameliorating microcirculation

Abstract

Abstract: AIM: To observe the effect of Pearl Bright Eyedrop on rabbit eyes microcirculation.METHODS: The rabbit eyeball conjunctiva microcirculation obstacle models by intravenous injection of macromolecule Dextran T 500 were prepared. The Pearl Bright Eyedrop's improvement to rabbit eye microcirculation wes observed and analysed using animal Microcir Culation analyzer.RESULTS: Pearl Bright Eyedrop which administered after 5, 15, and 30 minutes could significantly speed up the blood flow velocity of eyeball conjunctival arterioles and venules, improve blood flow pattern, reduce blood flow pattern points.CONCLUSION: Pearl Bright Eyedrop has good amelioration effect on rabbit eyeball conjunctiva microcirculation obstacle.

Key words: Pearl Bright Eyedrop, Rabbit, Eye microcirculation

CLC Number:

R965.2

CHENG Min, YE Xiao-di, MIAO Yun-ping, CHEN Ai-yin, ZHENG Gao-li. Experimental study of Pearl Bright Eyedrop on rabbit eyes ameliorating microcirculation[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(8): 856-859.

[1]	LIU Wengui, WANG Youjin, MA Kun, DAI Guoliang, SHEN Xianglei, WANG Wei, SI Haipeng. Effects of elemene injected in multiple ways on liver histology changes in rabbits [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(3): 277-282.
[2]	ZHOU Peng, SUN Yuan, ZHANG Shu-xia, XIA Ai-xiao, CHEN Sai-zhen, DU You-gong. Pharmacokinetic study of glipizide effected by roxithromycin in rabbits [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(2): 181-184.
[3]	LUAN Hai-yun, LI Jin-lian, WANG Shao-hua, ZHONG Wei-zhen, HAN Yan-tao. Determination of L-carnitine and its active metabolites in rabbit plasma and hepatic tissue by precolumn derivatization HPLC [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(6): 636-640.
[4]	DENG Zu-yue, KANG Hua, XIN Yan-fei, KUANG Rong. Effects of tea polyphenols on the serum lipid and inflammation factor in experimental atherosclerosis rabbits [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(3): 279-282.
[5]	ZHOU Yi, CHEN Man-hua, LIU Jin-hua, ZHANG Li-yun. Protection of atorvastatin on cardiac function following ischemia-reperfusion injury in rabbits [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(7): 786-789.
[6]	CUI Jun-chang, LIU You-ning, WANG Rui, TONG Wei-hang, LI Zhao-xia. Development of tissue cage infection model and study of efficacy of levofloxacin in treatment of staphylococcus aureus infection [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(3): 291-294.
[7]	FEI Hong-wen, WANG Xin-fang, XIE Ming-xing, HE Ya-le. Evaluation of tissue doppler echocardiography on detecting early myocardial relaxation abnormality in adriamycin-induced cardiomyopathy rabbits [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(7): 738-742.
[8]	PU Qi-song, YANG Jian-quan, LEI Jun, LI Chun-ping, LAN Da-rong, ZHANG Xiang, WU Ti-cheng, CAI Chun-yan. Development of cerebellum with 7 months orally phenytoin zinc in child-hood rabbits [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(11): 1294-1298.
[9]	FEI Hong-wen, WANG Xin-fang, XIE Ming-xing, HE Ya-le. Evaluation of adriamycin-induced dilated cardiomyopathy model in rabbits by echocardiography [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(1): 48-51.
[10]	LIN Chao-Xian, SHI Gang-Gang, LUO Wen-Hong, LI Hui, ZHENG Jin-Hong, GAO Fen-Fei. Pharmacokinetics of N-n-butyl haloperidol iodide determined by HPLCMS method in rabbits [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(8): 922-924.
[11]	DONG Liu-Yi, FAN Li, CHEN Zhi-Wu, JIANG Qin, FANG Ming, CEN De-Yi, CHEN Fei-Hu, ZHI Qiang. Effects of reteplase on fibrinolytic and coagulation systems in rabbits [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(7): 778-780.
[12]	LI Jia-Fu, ZHANG Mao-Shun¹, WANG Jia-Liang¹, FU Zhong-Yin¹. Effects of flavonoids of Hippophae rhamnoides L on intracellular free calcium concentration in cultured rabbit aortic smooth muscle cells [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(3): 305-307.
[13]	WANG Hui-Jiu, HUANG Xie-Nan, JIANG Qing-Song, WU Qin, SUN An-Sheng, SHI Jing-Shan. Effects of naftopidil's ramification-BWYJ on vascular activities and it's vasodilative mechanism [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(12): 1393-1397.
[14]	LI Nian-Sheng, HU Chang-Ping. Protective effects of shenmai injection on free radical-induced myocardial injury in isolated rabbit hearts [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2003, 8(6): 689-691.
[15]	WANG Wan-Tie, WANG Wei, XU Zheng-Jie, LINLI-Na, LI Dong. Change oflactic dehydrogenase activity andProtection ofl-arginine on ischemia-reperfusion injury in rabbits [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2003, 8(5): 548-550.

Experimental study of Pearl Bright Eyedrop on rabbit eyes ameliorating microcirculation

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments