Effect of alprostadil injection on lung injury in patients with paraquat poisoning

Abstract

Abstract: AIM: To investigate the clinical therapeutic effect of alprostadil injection on inflammatory response and lung injury in patients with paraquat poisoning and thus to improve clinical practice.METHODS: Thirty patients with paraquat poisoning were randomized into control and observation group (15 cases in each group), where the patients in control group received routine therapy and additional 10 μg alprostadil injection dissolved in 100 mL saline was administrated intravenously for 7 days in experimental group. Plasma levels of interleukine-6, 8 and matrix metalloproteinase-9 (MMP-9) were detected; arterial blood gas analysis and chest X-ray examination were performed at the first and seventh day of admission, and mortality compared between the two groups.RESULTS: Compare to control group, the levels of plasma IL-6, IL-8 and MMP-9 were decreased, the incidences of acute lung injury and systemic inflammatory response syndrome were lower in experimental group at seventh day of admission (P<0.05). There was no significant differences of mortality between the two groups (P>0.05).CONCLUSION: Alprostadil injection could protect the patients with paraquat poisoning agaist acute lung injury by attenuating inflammatory response.

Key words: Poisoning, Paraquat, Lung injury, Alprostadil

CLC Number:

R595

LV Wang, CHEN Xin-Guo, JIN Huan-Zhi, ZHANG Xue-Liang. Effect of alprostadil injection on lung injury in patients with paraquat poisoning[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(8): 910-913.

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