Progress of the molecular mechanisms research of gallbladder cancer lymphatic metastasis

Abstract

Abstract: Gallbladder cancer (GBC) is the most frequent biliary tract malignancy. Prognostic factors that influence the success of aggressive surgical therapy include depth of invasion, histologic grade, lymphatic or perineural invasion, and lymphatic metastasis. Lymphatic metastasis is a common way of metastasis. The molecular mechanism of lymphatic metastasis remains unclear. VEGF-C/VEGF-D and its receptor VEGFR-3 promote Lymphangiogenesis and play a key role in lymph node metastasis. p16 may increase the degree of malignancy, through mutation and methylation, which is related to lymphatic metastasis. Hypoxia inducible factor 1α (HIF-1α) induces the expression of VEGF-C/-D, promote Lymphangiogenesis and lymph node metastasis. In the gene family of matrix metalloproteinase (MMPs), MMP-2 and MMP-9 may be associated with the lymphatic metastasis, which can degradate extracellular matrix (ECM).

Key words: Gallbladder carcinoma, Lymphatic metastasis, Molecular mechanisms

CLC Number:

R966

ZHANG Lin, LI Mao-lan, LI Song-gang, WU Wen-guang, LIU Ying-bin. Progress of the molecular mechanisms research of gallbladder cancer lymphatic metastasis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(8): 919-923.

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