Study on the relationship between genetic variation and nonalcoholic fatty liver disease

Abstract

Abstract: Nonalcoholic fatty liver disease is a group of heredity-environment-metabolism stress disease. It is the most common chronic liver disease in the western country and the second common liver disease after viral hepatitis in our country. Nonalcoholic fatty liver disease is considered as a component of metabolism syndrome, which consists of obesity, type II diabetes mellitus, dyslipidemia and hypertension. Nonalcoholic fatty liver disease have been becoming a common cause of chronic liver diseases and transaminase abnormality. Recently, the genetic basis of Nonalcoholic fatty liver disease is attracting more and more attention. The studies between nonalcoholic fatty liver and genetic variations affecting fatty acid metabolism, insulin resistance, oxidative stress and so on were sumnarized.

Key words: Nonalcoholic fatty liver disease, Genetic variation, Gene, Gene polymorphism

CLC Number:

R575

JING Xian, LI Hui, DENG Xiao-lan, OUYANG Dong-sheng. Study on the relationship between genetic variation and nonalcoholic fatty liver disease[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(8): 950-956.

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