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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2012, Vol. 17 ›› Issue (9): 1022-1025.

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Correlation analysis of olanzapine plasma concentrations and individual intrinsic factors based on PLS model

YU Ling-yan, LOU Hong-gang, RUAN Zou-rong, JIANG Bo, CHEN Jin-liang   

  1. Division of Clinical Pharmacology, the 2nd Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang, China
  • Received:2012-02-09 Revised:2012-06-11 Published:2012-09-25

Abstract: AIM: To evaluate the relationship between olanzapine plasma concentrations and individual intrinsic factors. METHODS: The concentrations of olanzapine in plasma were determined by LC-MS/MS method. The PLS model was used to analysis the correlation between AGE, BMI, WBC, RBC, PLT, HB, Cr, BUN,TP, ALB,AKP, ALT and Cmax. RESULTS: Positive correlations between Cmax and BMI, WBC, BUN, TP, ALT and negative correlation between Cmax and RBC, PLT, HB, Cr, ALB, AKP were observed. Among the total, significant correlations were observed with BMI,WBC,RBC,BUN,TP. Successful fitting result was proved with predictive modeling analysis. CONCLUSION: Individual intrinsic factors should affect Cmax of olanzapine,which provided a useful tool for individualized drug therapy.

Key words: Partial least-squares regression (PLS), Olanzapine, Individual intrinsic factors

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