Prevention effect of 4-HPR on bladder tumor in SD rats: An in vivo experiment

Abstract

Abstract: AIM: To observe the curative effect of 4-HPR on bladder tumor using bladder tumor model induced by MNU in SD rats. METHODS: 70 SD rats was randomly divided into 5 groups: control group (Group A), module group (Group B), mould processing group (Group C, Group D, Group E). The bladder perfusion of treatment group was instilled 4-HPR, ADM and BCG respectively. A week after administration, the SD rats were put to death. The immunohistochemistry was used to detecte the expression of COX-2 and MVD, and the TUNEL technique was applied to examine apoptosis.RESULTS: The results of pathological specimens indicated that the 4-HPR, ADM and BCG inducing tumor had an obvious intervention effect (P<0.05); Besides, the 4-HPR could inhibit the expression of COX-2, the generation of capillaries, and the spur of apoptosis tumor cells (P<0.05).CONCLUSION: The 4-HPR, ADM and BCG to MNU had an intervention effect in carcinogenic process. The 4-HPR had no significant differences in anticancer effect compared with other groups, but had less side effect than the other groups.

Key words: Bladder tumor, 4-HPR, Bacillus Calmette-Guerin, Adriamycin

CLC Number:

R965.2

SHEN Qun-shan, HUANG Hou-bao, PAN Cai-ming, XUE Jun, CAI Zhang-yu, WANG Xiao, JIANG Shu-chuan. Prevention effect of 4-HPR on bladder tumor in SD rats: An in vivo experiment[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(9): 972-977.

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