Regulation of nuclear receptors on cytochrome P450 enzymes

Abstract

Abstract: Nuclear receptors are one superfamily of ligand-activated transcription factors and relate to regulating gene expression in drug metabolic processes. Nuclear receptors play an important role in growing development, metabolism and many physiological processes. Nuclear receptors including CAR, PXR, GR, AhR and PPAR mediate drug metabolism by regulating cytochrome P450 gene expression in vivo. This paper reviewed the regulation effect of several nuclear receptors on cytochrome P450 gene in order to provide molecular mechanism for drug interaction.

Key words: Nuclear receptors, Cytochrome P450, Regulate

CLC Number:

R969

HE Fang, ZENG Cai-wen, XIA Chun-hua, XIONG Yu-qing. Regulation of nuclear receptors on cytochrome P450 enzymes[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(10): 1195-1200.

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